Methadone and Suboxone should not be mixed.
Methadone is a full opioid agonist, meaning it “strongly” turns on opioid receptors in the brain. On the other hand, Suboxone is what we call a “partial opioid agonist” which means it “partially” turns on opioid receptors in the brain.
Suboxone binds more strongly to receptors in the brain, and thus mixing these two can precipitate withdrawal symptoms when Suboxone “kicks out” the methadone off of the brain receptors.
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