Can You Take Ibuprofen While on Suboxone?

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Yes, you can generally take ibuprofen while on Suboxone. But it’s always recommended to talk to your doctor before you take any medication while on Suboxone.

No Known Interactions Between Suboxone & Ibuprofen

There are no known interactions between Suboxone and ibuprofen.[1] This is true for all brand names of ibuprofen, including Advil and Motrin.

Ibuprofen is an anti-inflammatory drug that has a completely different mechanism of action than Suboxone. In addition, some pain medications can be sedating and should not be mixed with Suboxone. However, ibuprofen is NOT sedating and is therefore generally very safe to take with Suboxone.

Other Methods of Pain Management

If you are experiencing headaches, muscle pain, or another form of discomfort, first talk to your physician. They can assess the situation and help you pinpoint potential causes.

They may recommend you try non-medication-based forms of pain relief before using ibuprofen or another over-the-counter pain reliever. You may try the following:

  • Gentle massage
  • Sleeping
  • Dimming the lights
  • Drinking more water, ensuring overall hydration
  • Placing a warm or cool compress on the area where you are experiencing pain
  • Meditating
  • Easy movement, such as gentle stretching

If these methods don’t relieve your pain, it may be appropriate to take ibuprofen.

Stick to Prescribed Instructions

If you take ibuprofen, do not exceed the amount instructed on the medication’s labeling information. This means you shouldn’t take it more frequently or in a higher dose than advised. Also, be sure not to exceed the maximum dosage amount for 24 hours.

Keep Your Doctor Informed

Keep your MAT (Medication for Addiction Treatment) doctor informed of any pain medication you take, including ibuprofen. This ensures they have a full understanding of your physical pain and any medications you are taking. 

Since various medications can interact with Suboxone, it’s recommended that you inform your MAT physician before you take anything, including over-the-counter medications and supplements.[2]


  1. Drug Interactions Between Suboxone and Ibuprofen. Retrieved July 2022.
  2. Drug Interactions of Clinical Importance Among the Opioids, Methadone and Buprenorphine, and Other Frequently Prescribed Medications: A Review. The American Journal on Addictions. January–February 2010. Retrieved July 2022.

Elena Hill, MD, MPH

Elena Hill, MD; MPH received her MD and Masters of Public Health degrees at Tufts Medical School and completed her family medicine residency at Boston Medical Center. She is currently an attending physician at Bronxcare Health Systems in the Bronx, NY where she works as a primary care physician as well as part time in pain management and integrated health. Her clinical interests include underserved health care, chronic pain and integrated/alternative health.

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