Yes, multiple antibiotic medications have drug-drug interactions with Suboxone.
Antibiotics are medications that your healthcare provider prescribes to treat an infection caused by bacteria. Antibiotics will not treat infections caused by viruses (e.g., common cold, flu) or fungi (e.g., ringworm, oral thrush).
Antibiotics must be taken as directed and only when prescribed by your provider. Taking antibiotics when they are not recommended can lead to bacterial resistance (antibiotic will not work as well against the bacteria) and can cause unwanted side effects (e.g., diarrhea, upset stomach).
There are quite a few antibiotics from multiple drug classes that can interact with Suboxone. Therefore, you must always let your provider know that you are taking Suboxone before starting any new medications. Some of the most common antibiotics that interact with Suboxone include clarithromycin, erythromycin, minocycline, and rifampin.
If you are prescribed an antibiotic with a drug-drug interaction with Suboxone, it may still be safe to take the medication. However, your provider will discuss the risk versus benefit with you, and in most cases, they will adjust the dose of your antibiotic to accommodate for the interaction with Suboxone.
You must not stop taking any antibiotic therapy prescribed for you unless you discuss it with your provider first.