Is it safe to take Suboxone with trazodone?

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Yes, Suboxone is safe to take with trazodone under the supervision of your health care provider. 

What is trazodone?

Trazodone is typically used to treat major depressive disorder, but it can also be used in alcohol dependence, anxiety, and as a sleep aid. 

Trazodone interacts with many neurotransmitters (special communicating chemicals), including acetylcholine, norepinephrine, dopamine, and serotonin. It is thought to help improve the symptoms of depression by preventing the reuptake (decreased levels) of serotonin by nerves in the brain. As a result, more serotonin is available to stimulate other nerves.

Are there any risks in taking Suboxone with trazodone?

Risks of Taking Suboxone with Trazodone

Yes, some adverse effects can occur when Suboxone and trazodone are combined. 

Suboxone and trazodone usually are taken once daily at separate times (Suboxone in the morning and trazodone at bedtime). Still, since both agents can increase drowsiness and sedation, you must exercise caution before operating heavy machinery or driving until you know how they will affect you. 

In addition, neither medication should be taken with alcoholic beverages due to the risk of a severe breathing emergency and death from excessive sedation. 

Also, because both medications affect serotonin levels within your body, you may be at a higher risk for a condition called serotonin syndrome (serotonin levels are too high). Therefore, your doctor will monitor you closely if they believe taking both medications is appropriate for you.

Signs of Serotonin Syndrome

Some signs and symptoms of serotonin syndrome may include: 

  • Confusion 
  • Dizziness 
  • Excessive sweating
  • Fainting
  • High fever 
  • Hyperthermia
  • Muscle rigidity 
  • Rapid or irregular heart rate
  • Tremor 

If you believe you are experiencing serotonin syndrome, you must call your doctor or seek emergency services right away for severe symptoms.

Brittany Hoffmann-Eubanks, PharmD, MBA

Brittany Hoffmann-Eubanks, PharmD, MBA, received her Doctor of Pharmacy and Master of Business Administration degrees from Drake University College of Pharmacy and Health Sciences and completed her community pharmacy residency with Midwestern University and a local community pharmacy.

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