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Is it safe to take Suboxone with Prozac?

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Yes, you can take Suboxone and fluoxetine (Prozac) together, but some potential risks will require close monitoring. 

What is Prozac?

Fluoxetine (Prozac) is an antidepressant used to treat a variety of conditions such as depression, obsessive-compulsive disorder (OCD), bulimia, premenstrual dysphoric disorder (PMDD), and panic disorder. 

It belongs to a group of medications known as selective serotonin reuptake inhibitors (SSRIs). Fluoxetine works by increasing the amount of time that serotonin (a special communicating chemical called a neurotransmitter) stays active in the nerves within your central nervous system.

What happens when Suboxone and Prozac are taken together?

Signs of Serotonin Syndrome from Taking Suboxone and Prozac

Suboxone and fluoxetine can typically be taken together safely under the supervision of your provider.

While all medications have the potential to cause adverse effects, many individuals tolerate their medication with none or minimal side effects. Both Suboxone and fluoxetine can upset the stomach, cause diarrhea, constipation, sweating, and headaches. You should report any overly bothersome symptoms to your doctor promptly. 

Since both medications affect serotonin levels, you may be at a higher risk for a condition called serotonin syndrome (serotonin levels are too high). Therefore, your doctor will monitor you closely if they believe taking both medications are appropriate for you.  

Some signs and symptoms of serotonin syndrome may include: 

  • Confusion 
  • Dizziness 
  • Excessive sweating
  • Fainting
  • High fever 
  • Hyperthermia
  • Muscle rigidity 
  • Rapid or irregular heart rate
  • Tremor 

If you believe you are experiencing serotonin syndrome, you must call your doctor or seek emergency services right away for severe symptoms. 

Brittany Hoffmann-Eubanks, PharmD, MBA

Brittany Hoffmann-Eubanks, PharmD, MBA, received her Doctor of Pharmacy and Master of Business Administration degrees from Drake University College of Pharmacy and Health Sciences and completed her community pharmacy residency with Midwestern University and a local community pharmacy.

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