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Does Suboxone interact with other drugs or medications?

Buprenorphine interacts with other sedative medications—medications that make you tired and slow you down. These include medications like benzodiazepines: alprazolam (brand name: xanax), clonazepam (brand name: klonopin), diazepam (brand name: valium), and lorazepam (brand name: ativan); muscle relaxers; tranquilizers; sleeping agents; and alcohol. All these medications depress your central nervous system and have an additive effect. 

Taking too many can lead to respiratory depression (slowing or stopping of your breathing) and overdose. In low quantities, these might be safe with Buprenorphine, but if you are taking combinations of these medications, it will be very important to be monitored closely by your doctor and also report if you are feeling tired/sedated on these medications.

Other than sedatives, Buprenorphine has almost NO medication interactions. If you are taking HIV medications, it is important you check with your doctor about potential interactions with Suboxone.


Randi Sokol, MD, MPH, MMedEd

Randi Sokol, MD, MPH, MMedEd, is an Assistant Professor at the Tufts Family Medicine Residency Program and Instructor at Harvard Medical School. She is Board Certified in both Family Medicine and Addiction Medicine. She earned her B.A. at the University of Pennsylvania, her Medical Degree and Masters in Public Health from Tulane University, completed Family Medicine Residency at UC-Davis, and earned a Masters in Medical Education through the University of Dundee.

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