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Is it safe to take Suboxone with Buspar?

Brittany Hoffmann-Eubanks, PharmD, MBA profile image
By Brittany Hoffmann-Eubanks, PharmD, MBA • Updated Sep 18, 2023

Yes, you may safely take Suboxone and buspirone (Buspar) together if your doctor determines they are appropriate for your treatment.

What is Buspar? 

Buspirone (Buspar) is approved to treat generalized anxiety disorder or to help with the short-term relief of anxiety symptoms. Buspirone is a unique medication with its own drug class, meaning it is not pharmacologically similar to other anxiety medications. 

This medication is not an appropriate treatment for anxiety or tension caused by the stress of everyday life. 

The exact mechanism by which buspirone exerts its effects is unknown. However, the drug is highly attracted to the neurotransmitters serotonin, and to a lesser extent, dopamine (both important communicating chemicals in the brain). 

Buspirone’s effects on serotonin and dopamine may explain its ability to help relieve anxiety symptoms. Unlike other antianxiety medications, buspirone does not cause significant sedation. 

Are there any drug interactions between Suboxone and Buspar?

Things to Avoid While Taking Buspar and Suboxone

There are no known drug interactions between Suboxone and buspirone. Although buspirone has fewer sedative side effects, it is still prudent to avoid the consumption of alcohol. 

Suboxone should never be combined with alcoholic beverages due to the risk of a severe breathing emergency and death from excessive sedation. Also, driving or operating heavy machinery should be avoided until you know how you feel on either medication. 

Suboxone and buspirone should not be taken with grapefruit or grapefruit juice as it may cause unsafe levels of Suboxone and buspirone within your body.

By Brittany Hoffmann-Eubanks, PharmD, MBA

Brittany Hoffmann-Eubanks, PharmD, MBA, received her Doctor of Pharmacy and Master of Business Administration degrees from Drake University College of Pharmacy and Health Sciences and completed her community pharmacy residency with Midwestern University and a ... Read More

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