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Can you take Benadryl with Suboxone?

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Yes, you can take Benadryl with Suboxone, but with caution. 

What is Benadryl?

Benadryl is an antihistamine medication often used for allergies which can also be sedating. It should be used cautiously in combination with Suboxone. Antihistamine medications like Benadryl turn off histamine receptors. One of their side effects is drowsiness.

Side Effects of Taking Benadryl & Suboxone

Alternatives to Benadryl

If you are using Benadryl for allergies and are worried about becoming too sedated in combination with Suboxone, another option would be loratadine, sold under the brand name “Claritin”. Loratadine is also an antihistamine but is less sedating than Benadryl. 

Talk to your doctor about combining multiple sedating medications at a time. 

Elena Hill, MD, MPH

Elena Hill, MD; MPH received her MD and Masters of Public Health degrees at Tufts Medical School and completed her family medicine residency at Boston Medical Center. She is currently an attending physician at Bronxcare Health Systems in the Bronx, NY where she works as a primary care physician as well as part time in pain management and integrated health. Her clinical interests include underserved health care, chronic pain and integrated/alternative health.

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