Generally, the answer is no, especially compared to other opioids. Tolerance is defined as decreased sensitivity to the effects of opioids over time. Tolerance can develop in chronic opioid therapy regardless of opioid type, dose, route of administration, and administration. [from TIP 54]. Buprenorphine/naloxone (Suboxone), because it is a partial opioid agonist, usually creates less tolerance than full agonist medications; however, it is possible to build up tolerance to Suboxone over time, just as with most medications.