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Does Suboxone lower your opiate tolerance?

Generally, the answer is no, especially compared to other opioids. Tolerance is defined as decreased sensitivity to the effects of opioids over time. Tolerance can develop in chronic opioid therapy regardless of opioid type, dose, route of administration, and administration. [from TIP 54]. Buprenorphine/naloxone (Suboxone), because it is a partial opioid agonist, usually creates less tolerance than full agonist medications; however, it is possible to build up tolerance to Suboxone over time, just as with most medications. 

Medically Reviewed By Elena Hill, MD, MPH

Elena Hill, MD; MPH received her MD and Masters of Public Health degrees at Tufts Medical School and completed her family medicine residency at Boston Medical Center. She is currently an attending physician at Bronxcare Health Systems in the Bronx, NY where she works as a primary care physician as well as part time in pain management and integrated health. Her clinical interests include underserved health care, chronic pain and integrated/alternative health.

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