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What is buprenorphine?

Buprenorphine acts like a partial opioid in the brain, which is different from methadone, oxycodone, heroin, and fentanyl. Buprenorphine sits on the opioid receptors, thereby reducing cravings and preventing withdrawal symptoms. Because buprenorphine is a partial opioid agonist, it has a ceiling effect—this means that after a certain dose, there is no additional opioid effect, which ultimately decreases the risk for overdose. Buprenorphine treatment is often combined with naloxone, which results in the commonly known medication, Suboxone. Naloxone (commonly known as Narcan) is an opioid antagonist, which means it blocks opioids in the brain. Thus, the combination of buprenorphine with naloxone further discourages misuse of the medication.

Rebekah L. Rollston, MD, MPH

Rebekah L. Rollston, MD, MPH, is a board-certified Family Medicine Physician and Head of Research at Bicycle Health. She earned her Medical Degree from East Tennessee State University Quillen College of Medicine (in the Rural Primary Care Track) and her Master of Public Health (MPH) from The George Washington University Milken Institute School of Public Health. Dr. Rollston completed her residency at Tufts University and Cambridge Health Alliance, a Harvard-affiliated community healthcare system in Greater Boston, with emphases in addiction medicine and sexual & reproductive health. Her professional interests focus on social determinants of health & health equity, addiction medicine, gender-based violence, sexual & reproductive health, rural health, homelessness & supportive housing, and immigrant health. Dr. Rollston has published on these topics in The Lancet, Journal of Health Care for the Poor and Underserved, American Journal of Health Promotion, Journal of Appalachian Health, and Medical Care.

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Rebekah L. Rollston, MD, MPH

Rebekah L. Rollston, MD, MPH, is a board-certified Family Medicine Physician and Head of Research at Bicycle Health. She earned her Medical Degree from East Tennessee State University Quillen College of Medicine (in the Rural Primary Care Track) and her Master of Public Health (MPH) from The George Washington University Milken Institute School of Public Health. Dr. Rollston completed her residency at Tufts University and Cambridge Health Alliance, a Harvard-affiliated community healthcare system in Greater Boston, with emphases in addiction medicine and sexual & reproductive health. Her professional interests focus on social determinants of health & health equity, addiction medicine, gender-based violence, sexual & reproductive health, rural health, homelessness & supportive housing, and immigrant health. Dr. Rollston has published on these topics in The Lancet, Journal of Health Care for the Poor and Underserved, American Journal of Health Promotion, Journal of Appalachian Health, and Medical Care.

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