Like any medication, buprenorphine/naloxone (Suboxone) has side effects — but most are relatively mild and can be managed under close medical supervision, sometimes with relief from other over-the-counter medications. Most of these side effects, if at all, will occur at the very beginning of treatment and then subside as your body adapts to the new medication. Suboxone’s most common side effects include headache, nausea, dizziness, fatigue, insomnia, excessive sweating, stomach cramps, constipation, and dry mouth.
If a patient “feels sick” after taking buprenorphine/naloxone (Suboxone), most commonly, it is because they took Suboxone too soon after taking an opioid. This can cause “precipitated withdrawal,” which can be incorrectly mistaken as a side effect from the Suboxone itself as opposed to an unfortunate consequence of taking Suboxone too soon after using opioids. Therefore, make sure you talk to your doctor before starting Suboxone to prevent a “precipitated withdrawal.”