Buprenorphine/naloxone (Suboxone) has been known to have an effect on serum levels of testosterone in men; however, the clinical effects of this are unclear and don’t necessarily mean that there will be any changes in sexual function. Some men do occasionally report sexual dysfunction on Suboxone. However, this is less common in patients that have been on opioids prior. Compared to methadone and other full opioid agonist medications, sexual side effects are less common with Suboxone. If you experience sexual changes on Suboxone, discuss them with your provider.