Generally, low blood sugar is NOT a side effect of buprenorphine/naloxone (Suboxone). Suboxone can cause symptoms that may feel like low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness). However, this is very unusual, particularly in someone who does not have diabetes or other problems with blood sugar. If you have diabetes or a history of low blood sugar, it might be helpful to check your blood sugar at the time you feel these symptoms. If you are taking insulin or other treatment for diabetes, let your doctor know. However, many diabetic patients also take buprenorphine/naloxone (Suboxone) without issue.