Itching can be a side effect of opioid use. It is usually less severe with buprenorphine/naloxone (Suboxone) than with pure opioids like oxycodone or heroin. It can be difficult to treat and can be an ongoing problem. Sometimes, it may improve as the body adjusts to the opioid over time. Treatments like antihistamines can be helpful. Common specific antihistamines include Benadryl or loratadine.