The Relationship Between Schizophrenia & Addiction

June 24, 2022

Table of Contents

About 24 million people worldwide live with schizophrenia.[1] They may see or hear things others can't, and they may struggle with conversation, focus, and mood regulation. Many people with schizophrenia also struggle with substance use disorders (SUD). Up to half of all people with schizophrenia endorse drug or alcohol misuse, and more than 70% are dependent on nicotine.[2] People with schizophrenia have varied reasons for substance use. But all can get better through treatment programs that address both mental health and addiction simultaneously. 

The Connection Between Schizophrenia & Addiction 

People with schizophrenia may use substances for many different reasons. Some of the common reasons might include:

1. Symptom Relief 

Life with untreated schizophrenia is filled with unusual sights and sounds. People with this mental illness may know that their hallucinations aren't real, but they may still be frightened or disturbed by them. People with schizophrenia may use substances to reduce feelings of anxiety from hallucinations or delusions associated with their mental health condition. [3]

2. Medication Side effects

Prescription medications used to treat schizophrenia cause unwelcome side effects. Taking these medications can help people stay in control of their mental illness, may struggle with the side effects associated with psychotropic medications used to treat schizophrenia. Some patients may use substances like nicotine or alcohol to ameliorate some of the side effects of their medications [4]

3. Genetic Predisposition

Addiction and schizophrenia are very different, but the problems both arise from the brain. Researchers believe the same genes that can make someone vulnerable to substance use disorder (SUD) might be responsible for schizophrenia too, although this has certainly not been proven in all cases.[5] If this theory is correct, people with schizophrenia may simply be more genetically susceptible to substance use disorders. 

Substances as a Trigger for the Development of Schizophrenia

It is not known the root causes of schizophrenia, but there is a fair amount of research that suggests that substance use can be the trigger to developing the new onset of schizophrenia. For example, some studies have shown that drugs like Marijuana can be the precipitator of a first psychotic episode which then results in persistent mental illness. [6] For some people, drug use may be partially responsible for the onset of schizophrenia symptoms.

Treatment for Schizophrenia & Addiction 

People with both schizophrenia and SUD can recover. While healing is different for each person, experts say someone can consider themselves “in recovery” or “in remission” when they:[7]

  • Keep their schizophrenia symptoms under control 
  • Don't misuse substances
  • Live independently 
  • Have a job or another means of giving back to society  
  • Connect with friends and family 
  • Have a good quality of life or a life with meaning/purpose 

A typical treatment plan involves several elements:[8]

  • Early addiction treatment: Medications and time help someone transition into sobriety. Some people need help in inpatient facilities, while others can follow treatment plans at home. An assessment from a treatment professional helps to determine how treatment begins.
  • Medications: Schizophrenia therapies soothe brain chemical imbalances. And prolonged use of some substances, including opioids and alcohol, causes brain cell imbalances that respond to medications.
  • Psychotherapy: People learn how to change the way they think and respond in one-on-one and group therapy sessions. This is where much of the work of addiction treatment takes place.
  • Support groups: Connect with others in recovery and learn how they manage schizophrenia and substance misuse. Feel part of a community of peers. You can often turn to these people when times get tough.
  • Supportive housing: Sober living homes and similar facilities give people a place to recover with fewer relapse pressures. 

It takes time to recover from addiction and schizophrenia. And there is no cure for either condition, but both can be managed for life. But with the right treatment program, you can get better.

Schizophrenia & Addiction FAQs 

Do people with schizophrenia have higher rates of substance misuse?

People with schizophrenia are 4.6 times more likely than the general population to have a substance misuse diagnosis.[2] The reasons for this are not fully understood but may involve a combination of genetic and environmental risk factors. 

What substance use disorder is most common with schizophrenia?

People with schizophrenia often misuse nicotine, alcohol, cocaine, and cannabis.[2]

How does alcohol affect a person with schizophrenia?

Long-term alcohol misuse can cause a withdrawal syndrome characterized by hallucinations. People with schizophrenia may confuse their withdrawal symptoms for schizophrenia symptoms. 

Does drug use cause schizophrenia?

Not exactly, no. While it is not thought that drug use alone directly causes schizophrenia, drug use has been known to be the precipitating factor to a first psychotic episode in many patients that then later develop persistent schizophrenia. Drug use alone is not the cause, but if present, may increase the likelihood that someone who is already genetically at risk to develop schizophrenia to actually start to display symptoms of the condition. 

Why do people with schizophrenia misuse substances?

The reasons are variable; some people with schizophrenia attempt to self-medicate negative symptoms of the disorder. For example, they may take drugs or drink alcohol in an effort to offset some of the depressive symptoms of schizophrenia. They may use substances for stress relief associated with the hallucinations or delusions that are associated with the condition. And they may simply have more of a genetic predisposition for SUD than the general population. 

Elena Hill, MD, MPH

Elena Hill, MD; MPH received her MD and Masters of Public Health degrees at Tufts Medical School and completed her family medicine residency at Boston Medical Center. She is currently an attending physician at Bronxcare Health Systems in the Bronx, NY where she works as a primary care physician as well as part time in pain management and integrated health. Her clinical interests include underserved health care, chronic pain and integrated/alternative health.

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  1. Schizophrenia. World Health Organization. January 2022. Accessed May 2022. 
  2. Substance Abuse in Patients with Schizophrenia. Dialogues in Clinical Neuroscience. March 2006. Accessed May 2022. 
  3. Reasons for Illicit Drug Use in People with Schizophrenia: Qualitative Study. BMC Psychiatry. November 2010. Accessed May 2022.
  4. Problematic Drug Use Among Outpatients with Schizophrenia and Related Psychoses. Frontiers in Psychiatry. October 2021. Accessed May 2022. 
  5. The Link Between Schizophrenia and Substance Use Disorder: A Unifying Hypothesis. Schizophrenia Research. April 2019. Accessed May 2022.
  6. Cannabis Use and Age at Onset of Schizophrenia. American Journal of Psychiatry. March 2004. Accessed May 2022. 
  7. Schizophrenia and Substance Use. Schizophrenia Society of Canada. Accessed May 2022. 
  8. Substance Use Disorders. National Alliance on Mental Illness. May 2020. Accessed May 2022. 

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