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Long-Term Suboxone Use: What You Should Know

Peter Manza, PhD profile image
Reviewed By Peter Manza, PhD • Updated Aug 4, 2023

Most people are accustomed to short courses of medication. We get an infection, and we take antibiotics, and then we move on. Suboxone is different. 

Suboxone quells your opioid use disorder (OUD) symptoms, allowing you to live a life free from addiction. But for many people, quitting the medication means returning to opioid misuse. Staying on the medication is the best way for many people to retain their life in recovery over the long term. 

Your doctor can help you determine how long you should take Suboxone. And if you’re considering quitting your medication because of side effects, your doctor can help with that too. 

What Are the Long-Term Effects of Suboxone Use?

Suboxone contains buprenorphine and naloxone, and doctors manage your dose very carefully. If you remain on the drug for long periods, you could experience health issues. Your doctor can monitor you closely and help if they appear.

These are a few issues associated with long-term Suboxone: 

Withdrawal Problems

The buprenorphine in Suboxone is a partial opioid agonist. All drugs in this class can cause physical dependence, meaning people can feel sick when they don’t take their medications.[1]

Withdrawal symptoms include the following:

  • Headache
  • Diarrhea
  • Flu-like symptoms
  • Watery eyes

Mixing Suboxone with alcohol or other depressants can make withdrawal symptoms worse, and it is also very dangerous. 

Liver Issues

Each dose of Suboxone is processed by your liver. If you remain on the medication for a long time, you could do damage to this critical organ, though this happens rarely in people without pre-existing liver problems.[1] You could develop jaundice (where your skin turns yellow), or you could have no symptoms at all. Regular monitoring can help your doctor spot this problem. 

Mental Health 

Some people experience a so-called flattened aspect while taking Suboxone. The medication calms the brain, making people less likely to flare into anger or sweep into depression. This could be a benefit, but it could also make you feel unlike yourself. 


Many believe that people shouldn’t use medications like Suboxone for a long time. Some doctors even hold this opinion.[2] They are incorrect, but the longer you stay on the medication, the more unpleasant comments you might hear from people who don’t understand what you’re doing. 

What Are the Benefits of Long-Term Suboxone Use?

Experts recommend long-term maintenance medication for OUD.[3] People who remain on Suboxone long-term are much more likely to experience sustained recovery from OUD, resulting in fewer instances of opioid misuse and fatal overdose due to such misuse.[4]

With OUD, the potential for relapse remains high in some individuals, even after months or years of abstinence from opioids.[5] As a result, continuing medications can be crucial during the first few years of recovery. Remaining on Suboxone greatly reduces the likelihood of relapse.

Long-term Suboxone use is not associated with any significant health effects.

If you have been taking Suboxone for a long time, you may experience withdrawal when you stop taking the medication. This can be managed with a tapered approach to stopping use.[6] 

If you and your doctor decide you can safely stop taking Suboxone, your doctor will design a tapering schedule to minimize withdrawal symptoms during the transition period.

Potential Suboxone Side Effects

Side effects of Suboxone can occur with both short-term and long-term use. Some stomach discomfort may occur when you first start taking Suboxone, but this should generally dissipate within a few days.

Other potential side effects include the following:

  • Blurry vision
  • Constipation
  • Diarrhea
  • Nausea
  • Headache
  • Insomnia
  • Tongue pain
  • Mouth numbness
  • Backaches

These side effects are rare, so talk to your doctor if you experience them. They are not more common with long-term use, so if you didn’t experience side effects initially, it’s unlikely you will have them down the road.

Should You Stay on Suboxone Long Term?

If Suboxone is helping your recovery, doctors usually recommend staying on it on a long-term basis and even for life if necessary. Suboxone and other medications for OUD (MOUD) reduce the likelihood of relapse.[7]

If you stop taking MOUD and relapse to opioid misuse, you have a high potential for overdose since you haven’t been misusing opioids in a while, and your body may have decreased tolerance to the doses of opioids you were previously taking. 

If you take the same amount used before treatment with MOUD, the dose will likely lead to an overdose since your tolerance has declined. Opioid overdose can be fatal.

Issues are more commonly seen with short-term use of Suboxone or MOUD.[3] People who stop using MOUD too soon are more likely to relapse to opioid misuse and experience overdose. Because of this, it’s generally recommended that patients remain on Suboxone as long as needed, even indefinitely, to support their recovery from opioid use disorder.

Reviewed By Peter Manza, PhD

Peter Manza, PhD received his BA in Psychology and Biology from the University of Rochester and his PhD in Integrative Neuroscience at Stony Brook University. He is currently working as a research scientist in Washington, DC. His research focuses on the role ... Read More

  1. Buprenorphine. StatPearls. May 2022. Accessed January 2023.
  2. "You're Not Supposed to Be On It Forever:" Medications to Treat Opioid Use Disorder Related Stigma Among Drug Treatment Providers and People Who Use Opioids. Substance Abuse: Research and Treatment. February 2022. Accessed January 2023.
  3. Impact of Long-Term Buprenorphine Treatment on Adverse Health Care Outcomes in Medicaid. HealthAffairs. May 2020. Accessed January 2023.
  4. Medication-Assisted Treatment of Opioid Use Disorder. Harvard Review of Psychiatry. April 2015. Accessed January 2023.
  5. Comparative Effectiveness of Extended-Release Naltrexone Versus Buprenorphine-Naloxone for Opioid Relapse Prevention (X:BOT): A Multicentre, Open-Label, Randomised Controlled Trial. The Lancet. January 2018. Accessed January 2023.
  6. Discontinuation of Buprenorphine Maintenance Therapy: Perspectives and Outcomes. Journal of Substance Abuse Treatment. December 2014. Accessed January 2023. 
  7. Discontinuing Buprenorphine Treatment of Opioid Use Disorder: What Do We (Not) Know? The American Journal of Psychiatry. February 2020. Accessed January 2023.

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