Over-the-counter (OTC) medications cannot stop opioid withdrawal entirely, but certain OTC medications can relieve symptoms of withdrawal. Loperamide (Imodium) helps relieve diarrhea. Non-steroidal anti-inflammatory drugs, or NSAIDs (such as ibuprofen or naproxen), can help ease the pain of withdrawal symptoms such as headaches or chills. Ondansetron can help minimize nausea. Bentyl can be used to relieve abdominal cramping. While these medicines can be helpful to a certain degree, MAT (either Methadone or buprenorphine/naloxone (Suboxone)) is still the most effective treatment for preventing opioid withdrawal.