The FDA drug approval of buprenorphine/naloxone (Suboxone) is for 12 months. While the FDA stated policy is to avoid using expired medications, talk to your pharmacist about whether you might still be able to use Suboxone after its expiration date has passed. How long the medication remains safe and effective depends on many factors, including how and where the medication is stored. Buprenorphine/naloxone (Suboxone) should be stored at room temperature, at about 77°F (25°C), and protected from moisture and prolonged exposure to light. As with all medicines, keep them out of the reach of children.