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How long does Suboxone stay in your system?

Buprenorphine/naloxone (Suboxone) stays in your system for 28-42 hours after sublingual (under the tongue) administration via films or tablets, which are the most common route for buprenorphine/naloxone (Suboxone) treatment. Interestingly, when it was initially used, buprenorphine/naloxone was often given every 2 days because of its long duration of action.

For the treatment of opioid use disorder, buprenorphine/naloxone (Suboxone) is now usually prescribed as a daily medication. Some patients choose to divide their daily dose so they can take it two or three times a day. However, taking it once a day should cover almost all the opioid receptors in the brain at once, preventing withdrawal symptoms, cravings, and overdose from other opioids at least for the next 24 hours. So, waking up and taking buprenorphine/naloxone (Suboxone) first thing in the morning is a good strategy to maximize recovery success over the next 1-2 days.

Rebekah L. Rollston, MD, MPH

Rebekah L. Rollston, MD, MPH, is a board-certified Family Medicine Physician and Head of Research at Bicycle Health. She earned her Medical Degree from East Tennessee State University Quillen College of Medicine (in the Rural Primary Care Track) and her Master of Public Health (MPH) from The George Washington University Milken Institute School of Public Health. Dr. Rollston completed her residency at Tufts University and Cambridge Health Alliance, a Harvard-affiliated community healthcare system in Greater Boston, with emphases in addiction medicine and sexual & reproductive health. Her professional interests focus on social determinants of health & health equity, addiction medicine, gender-based violence, sexual & reproductive health, rural health, homelessness & supportive housing, and immigrant health. Dr. Rollston has published on these topics in The Lancet, Journal of Health Care for the Poor and Underserved, American Journal of Health Promotion, Journal of Appalachian Health, and Medical Care.

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Rebekah L. Rollston, MD, MPH

Rebekah L. Rollston, MD, MPH, is a board-certified Family Medicine Physician and Head of Research at Bicycle Health. She earned her Medical Degree from East Tennessee State University Quillen College of Medicine (in the Rural Primary Care Track) and her Master of Public Health (MPH) from The George Washington University Milken Institute School of Public Health. Dr. Rollston completed her residency at Tufts University and Cambridge Health Alliance, a Harvard-affiliated community healthcare system in Greater Boston, with emphases in addiction medicine and sexual & reproductive health. Her professional interests focus on social determinants of health & health equity, addiction medicine, gender-based violence, sexual & reproductive health, rural health, homelessness & supportive housing, and immigrant health. Dr. Rollston has published on these topics in The Lancet, Journal of Health Care for the Poor and Underserved, American Journal of Health Promotion, Journal of Appalachian Health, and Medical Care.

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