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How long does Suboxone stay in your system?

Buprenorphine/naloxone (Suboxone) stays in your system for 28-42 hours after sublingual administration (via films under the tongue), which is the most common route for buprenorphine/naloxone (Suboxone) treatment. Intramuscular, intravenous, and transdermal formulations have varying half-lives in your bloodstream.

Rebekah L. Rollston, MD, MPH

Dr. Rollston is a Family Medicine Physician at Cambridge Health Alliance, Affiliate Editor-in-Chief of the Harvard Primary Care Blog, and Founder of Doctors For A Healthy US, LLC. She earned her Medical Degree from East Tennessee State University Quillen College of Medicine and her Master of Public Health from The George Washington University. Her professional interests focus on social influencers of health & health disparities, addiction medicine, sexual & reproductive health, homelessness & supportive housing, and rural health.

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