
Dilaudid is the brand name of the potent opioid hydromorphone, which is prescribed to relieve moderate to severe pain.
As an opioid medication, Dilaudid can suppress the central nervous system and lead to a potentially life-threatening overdose, especially when misused.
Dilaudid is habit-forming even when taken as directed. Physical and emotional withdrawal symptoms may appear when the medication is stopped.
Dilaudid is commonly misused, and it is highly addictive. Nearly 2.5 million Americans ages 12 and older had an opioid use disorder (OUD) involving a prescription pain reliever such as Dilaudid in 2020.[1]
OUD is a treatable disease with several evidence-based care options that support ongoing recovery.
Dilaudid is a prescription narcotic pain reliever containing the opioid drug hydromorphone.
Dilaudid is available in tablet form, rectal suppositories, oral solutions, injectable formulations and as an extended-release tablet.
The liquid formulation is generally taken every three to six hours as needed, while the tablet is taken every four to six hours.
The extended-release formulation is designed to be taken by those who are opioid-tolerant and require around-the-clock pain management.[2] It may be used when other treatment methods are not an option.
As an opioid drug, Dilaudid is a central nervous system depressant that slows heart rate and respiration while lowering blood pressure and body temperature. The drug also binds to opioid receptors in the brain to block pain.
Many medications make up the opioid class, but Dilaudid is among the most dangerous.
Dilaudid is between two and eight times more potent than morphine.[3] It also has a greater sedation effect and a shorter duration of action than morphine. It’s capable of working quickly and changing your central nervous system in potentially dangerous ways.
Dilaudid is prescribed for moderate to severe pain. If you're in significant pain and other medications aren't helping, your doctor might use Dilaudid.
A history of opioid misuse can make weaker drugs less effective, so Dilaudid may be the only option that works.

Dilaudid suppresses the central nervous system and can cause sedation, drowsiness, breathing problems, a slow heart rate and reduced blood pressure.
These are other potential Dilaudid side effects:[2]
More severe side effects can also occur, including the following:
If you experience serious side effects, seek immediate medical attention. You may need a different method to ease pain.
Your doctor must prescribe Dilaudid and will check your medical history before offering you the drug. Some people shouldn't use it.
Your doctor may discuss the following issues before prescribing Dilaudid:[4]
Dilaudid can also make you feel sleepy and disoriented. This can pose risks when driving or operating machinery, and extreme caution is warranted.
Dilaudid can interact with a variety of both prescription medications and supplements.[2] Before you start using this medication, tell your doctor about all the prescriptions and over-the-counter drugs you take.
Dilaudid can interact with the following:
Dilaudid can potentially interact with even more medications than those listed. Be sure to talk to your doctor about anything you are taking before beginning Dilaudid.
About three-quarters of the nearly 92,000 drug overdose deaths in 2019 in the United States involved an opioid drug like Dilaudid.[5]
Opioid drugs slow heart and breathing rates. Take too much, and those doses can lead to death. Understanding what an overdose looks like is critical, as life saving medication can reverse an episode.
An opioid overdose can have the following signs:
Naloxone, available without a prescription nationwide in pharmacies like those run by CVS, can reverse an overdose if applied immediately.[6] Once you've delivered the dose, call 911 and follow the operator's instructions.
Dilaudid is a habit-forming medication. Regular use allows the brain and body to get used to its interaction, and dependence can form. When this happens, withdrawal symptoms can occur as soon as the drug wears off.
Withdrawal symptoms can be both psychological and physical. They may include the following:
Dilaudid is a commonly misused painkiller.[3] Its street names include dust, footballs, dillies, D, smack and juice.
The medication is often diverted through doctor shopping, forged prescriptions, and nursing home and pharmacy robberies.
Any use of the medication outside of its prescription and dosing directions is considered misuse. But some people take steps to make the drug more powerful, including chewing the tablets, crushing and snorting, dissolving and injecting them, or altering them to take them in a way other than intended. Misusing dilaudid in these ways makes it even more dangerous and potentially life-threatening.
These are some things to look for that can indicate Dilaudid misuse:
Two of the most serious side effects of Dilaudid misuse are overdose and opioid use disorder (OUD).
Dilaudid is a powerful narcotic that can lead to fatal overdose, especially if misused or taken with other substances like sedatives or alcohol.
It is also highly addictive. Misusing the medication increases the risk of developing OUD.
Treatment for Dilaudid misuse and OUD can include either inpatient or outpatient options. Both models often include the following:
Treatment programs cater to each individual specifically to promote lasting recovery. If you're misusing Dilaudid, reach out for help to create a treatment plan that's right for you.

Peter Manza, PhD received his BA in Psychology and Biology from the University of Rochester and his PhD in Integrative Neuroscience at Stony Brook University. He is currently working as a research scientist in Washington, DC. His research focuses on the role of the brain dopamine system in substance use disorders and in aging. He also studies brain function in obesity and eating disorders.