Codeine withdrawal symptoms occur when someone who is physiologically dependent on this opioid drug suddenly stops taking it. [1] These symptoms tend to be flu-like in nature, incluidng nausea, vomiting, muscle and joint pain, sleep disturbances, excessive sweating, and anxiety.[2],[3]
Although these symptoms can be unpleasant and distressing, they don’t tend to be life-threatening, although some complications can be dangerous if left untreated. Fortunately, professional codeine detox treatment can provide you with 24-hour care, supervision and monitoring to ensure your comfort and safety.
Codeine is often combined with Tylenol in a combination mediation known as Tylenol 3. It is usually prescribed as a painkiller or as a cough suppressant in severe cases.
Codeine withdrawal syndrome is a manifestation of physical dependence, and physical dependence develops along with chronic codeine use and addiction. [1]
When you take codeine regularly, you experience neuroadaptations, or changes in the brain chemistry and functioning. Once your brain adapts to the presence of codeine, it needs this drug or another opioid in order to function without you feeling seriously uncomfortable.[1]
When you suddenly stop taking codeine, your neurons release excessive amounts of noraderenaline, resulting in codeine withdrawal symptoms like diarrhea, jitters, anxiety and muscle cramps.[1]
Codeine withdrawal symptoms are similar to withdrawal from other opioids and typically include: [1],[2],[3]
Codeine withdrawal syndrome can range from mildly unpleasant to severe and painful, depending on many different factors.
Opioid withdrawal is rarely life-threatening, although some fatalities have occurred, particularly in the context of incarceration. This is often due to complications caused by opioid withdrawal symptoms like severe diarrhea and vomiting, which can cause dehydration and elevated sodium levels.[5]
The best way to stay safe and ensure your comfort during codeine withdrawal is to seek out medical detox treatment where you can receive withdrawal medications that reduce symptoms and cravings.
The severity of your codeine withdrawal symptoms may depend on many factors, such as:
Codeine is a short-acting opioid drug, which means the withdrawal symptoms come on fast and typically resolve within about one week.[6]
Generally, those who are dependent on or addicted to codeine will experience withdrawal symptoms within about 6-12 hours after their last dose. These symptoms tend to peak in intensity within 1-3 days, at which point they may experience severe gastrointestinal issues and muscle pain. Then symptoms are expected to dissipate and resolve within 5-7 days.[6]
Time Since Last UseExperience6-12 hoursCodeine withdrawal symptoms appear1-3 daysSymptoms peak in severity, very distressing5-7 daysSymptoms gradually disappear
Once your acute codeine withdrawal symptoms resolve, you may experience post-acute withdrawal, which are typically less intense symptoms that can last for weeks, months, or even years after you quit using codeine. Protracted withdrawal symptoms may include:[6]
Codeine withdrawal can be very distressing, but thankfully, detox treatment can help. The Substance Abuse and Mental Health Services Administration (SAMHSA) recommends around-the-clock care for opioid withdrawal because of how uncomfortable it can be.
Medical detox services for codeine withdrawal can occur in several settings, such as:
When you attend a codeine detox program, you’ll receive many benefits and treatment modalities, such as:
Methadone and buprenorphine are medications that can alleviate codeine cravings and minimize withdrawal symptoms during acute detox from codeine. They can also be prescribed on an ongoing basis to promote long-term recovery. You can access methadone at a specialized clinic but buprenorphine or Suboxone is available through doctors, both in-office and online.Some treatment providers, like Bicycle Health, offer telehealth services, so you can receive MAT in virtually any location. This makes medications for opioid use disorder much more accessible, helping people to get the vital help they need more easily and conveniently.
Peter Manza, PhD received his BA in Psychology and Biology from the University of Rochester and his PhD in Integrative Neuroscience at Stony Brook University. He is currently working as a research scientist in Washington, DC. His research focuses on the role of the brain dopamine system in substance use disorders and in aging. He also studies brain function in obesity and eating disorders.
