Your plan for starting buprenorphine (Suboxone) at home

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The following directions have been prescribed by a licensed medical provider for the  individual named above, may not be redistributed, and are not to be used by any other person for any reason.

Micro induction

Introduction

This video series contains your instructions to start buprenorphine (Suboxone) safely at home. Watch the series completely, and if anything is unclear let us know through chat in the Bicycle Health app.

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Hello and welcome to Bicycle Health. This video was created to provide you with more information and guidance on taking Suboxone safely while at home. Feel free to rewind this video or contact us if you have any more questions. Let’s get started.

What is Buprenorphine & Naloxone?

It’s an effective first-line medication for opioid use disorder that prevents opioid overdose and restores normal stability of opioid receptor activity when taken daily as directed.

After initially adjusting to the medication, a person taking buprenorphine (Suboxone) at an effective daily dose should feel neither withdrawal nor any impairment or high from the medication.  

Buprenorphine (Suboxone) reduces the potential of other opioids to cause a ‘high’ by maintaining stable, low-level activation of the opioid receptor system, and preventing other opiods from fully accessing opioid receptors.

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Buprenorphine is an effective first-line medication for the treatment of opioid use disorder. Suboxone is the brand name for a combination of buprenorphine and naloxone. This is the medication we offer to patients here at Bicycle Health. Buprenorphine is an opioid that binds to the opiate receptors in the brain but only partly activates them. This relieves withdrawal symptoms, decreases cravings, and protects against relapse long-term by blocking other opioids from binding to the receptor. It’s usually a once daily medication. And because buprenorphine doesn’t fully stimulate the opioid receptor, there is no feeling of a “high” while taking the medication. It restores stability to the opioid receptors

The second ingredient, Naloxone, is used in conjunction with buprenorphine to help deter abusing the medication. It has no effect and is not even absorbed when the medication is dissolved in the mouth as directed; it helps prevent misuse of the medication by causing withdrawal injected.

Why a withdrawal state is important to start?

“Precipitated Withdrawal” is an intense, sudden onset of severe withdrawal that will occur if buprenorphine (Suboxone) is started too soon, before the effects of other opioids have worn off adequately.

Avoid precipitated withdrawal by following these instructions carefully and by NOT starting buprenorphine (Suboxone) sooner than directed.  Precipitated Withdrawal will not occur if moderate withdrawal is allowed to onset gradually before starting buprenorphine (Suboxone).

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Buprenorphine is an effective first-line medication for the treatment of opioid use disorder. Suboxone is the brand name for a combination of buprenorphine and naloxone. This is the medication we offer to patients here at Bicycle Health. Buprenorphine is an opioid that binds to the opiate receptors in the brain but only partly activates them. This relieves withdrawal symptoms, decreases cravings, and protects against relapse long-term by blocking other opioids from binding to the receptor. It’s usually a once daily medication. And because buprenorphine doesn’t fully stimulate the opioid receptor, there is no feeling of a “high” while taking the medication. It restores stability to the opioid receptors

The second ingredient, Naloxone, is used in conjunction with buprenorphine to help deter abusing the medication. It has no effect and is not even absorbed when the medication is dissolved in the mouth as directed; it helps prevent misuse of the medication by causing withdrawal injected.

How to read the dose and cut the tabs/films

  • 8mg - This is the amount of buprenorphine (Suboxone) in the film or tablet
  • 2mg - This is the amount of naloxone in the film or tablet

To start buprenorphine (Suboxone) effectively, it is usually necessary to divide the films or tablets into smaller doses for the first 1 to 3 days.  Be sure you understand the directions and feel confident in your ability to do so in a clean, dry, precise way.

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Suboxone has 4 different strengths: 2/0.5, 4/1, 8/2 & 12/3. These numbers are in milligrams or mg. When reading the medication dosing, it is important to know that the first number represents the amount of buprenorphine in each film or tab and the second number represents the amount of naloxone in each film or tab. For our purposes, we will focus only on the first number for the buprenorphine. This gives us 2mg, 4mg, 8mg and 12mg strengths. The availability of dose strength and tabs vs films is based on pharmacy stock and is subject to insurance approval. In our treatment setting the most common doses used are 2mg and 8mg and we will use these as your reference throughout the remainder of these videos.

During your treatment, it may be necessary to divide the film or tab into smaller pieces. By doing so, we can provide you with the most ideal daily dose while also ensuring you can access available medication at your pharmacy. To cut your tablets we ask that you purchase a tablet cutter from your local pharmacy or use a clean, sharp knife. This helps ensure precise and equal division of the medication. Please do not use a dull object, tearing, or your teeth to divide the medication. A sharp knife on a dry cutting board will work but is also a hazard for cutting your hands, so we don’t recommend it. To cut your films, you may use clean, sharp scissors, and place the remaining film back into the original foil package, or into an airtight/humidity- proof package or a pill container at your local pharmacy.

Preparation, and First Dose

Information about Common over-the-counter medications that may be helpful before, while, or also after starting buprenorphine (Suboxone).

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Preparing to for your induction to Suboxone will help keep the process as smooth as possible while you are experiencing withdrawal symptoms. If you can, plan for the time you expect to be in withdrawal: take time off work and be in a calm setting with support from family or a friend. Be close to a bathroom. Stay well-hydrated with water or electrolyte drinks. Opioid withdrawal is generally not medically dangerous but is very uncomfortable, so it’s important to expect that. Be sure to review any other medications your provider has prescribed to help with your withdrawal symptoms and understand how and when to use them. Also, have an over-the-counter pain reliever and anti-diarrhea medication available.

Here is a list of useful materials you will need for your induction: your Suboxone medication, a tablet cutter and/or a clean, sharp pair of scissors and a pill box for storage. Review the link to our description of common over-the-counter support medications below.

Wait time, Assessing your withdrawal with the SOWS

The most important step for a comfortable at-home treatment start is to WAIT long enough between your last use of any other opioid and your first dose of buprenorphine (Suboxone).

Your Bicycle Health provider has told you the MINIMUM wait time before starting to consider your first dose of buprenorphine (Suboxone). Follow the wait-time they gave you. If you’ve forgotten, ask through chat in the Bicycle Health app. If you’d like to know more about how your provider determined the wait time, or if you’d like to check their work yourself :), here’s some more information about wait-times.

Once you have waited the amount of time directed, proceed to the next video segment to complete a set of questions called the SOWS (Subjective Opioid Withdrawal Scale) test.  The SOWS is a set of 16 short questions.  When answering, select the response that best describes how your are feeling RIGHT NOW.

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The most important part of ensuring a safe Suboxone start, is waiting long enough between your last opioid use and your first Suboxone dose. Your Bicycle Health provider will have told you the MINIMUM amount of time to wait before starting to assess your level of withdrawal. Wait the amount of time they told you, then complete the Subjective Opioid Withdrawal Scale (SOWS) below to assess your level of withdrawal. If you don’t remember the amount of time they told you to wait, ASK, and we’ll be glad to help. Waiting longer is safer than accidentally starting Suboxone too soon.

SOWS Calculator

After waiting for AT LEAST the amount of time directed by your Bicycle Health provider, answer the 16 questions above based on how you’re feeling RIGHT NOW.

The test is a validated way to determine whether it is safe to start buprenorphine (Suboxone) now, or whether it’s necessary to wait longer.  Follow the direction you receive above after completing the test.

Why is this important?

Hovering over why is this important expands the below information:

You’ve already waited the MINIMUM amount of time for the AVERAGE person to have no or very little opioid remaining in their body, but you’re not the average person; your metabolism is uniquely yours.  

The way you feel is the only sure way to determine when you have sufficiently little opioid remaining in your body to start buprenorphine (Suboxone) without causing worsened withdrawal.  We know it’s very challenging to wait for moderate withdrawal, but it’s worth it because you’ll want the medication to WORK when you take it instead of making you feel worse.

Taking your first dose and expectations

Buprenorphine must be dissolved under the tongue or between the gums and cheek (diagram here) to be effective.  If you swallow it, it won’t work at all! 

If you eat or drink shortly before taking buprenorphine, that increases saliva production and swallowing, and decreases effectiveness of the medication.

Now, place 2mg of buprenorphine under your tongue.

This is one-quarter (¼) of an 8mg film or tablet.

Wait until it is completely dissolved.  This takes 10 minutes.

Once completely dissolved, it’s ok to either swallow or spit any remaining saliva in your mouth.

After the medication dissolves, it’s normal to feel either a little better, a little worse, or no change at all.  It’s not normal to feel sudden, severe worsening of withdrawal, or to feel dizziness, sedation, or difficulty breathing.  Advance to the next video now to learn more about normal vs abnormal reactions to a first dose.  Be sure not to take your second dose until at least 2 hours have passed since your first dose.

Precipitated withdrawal and what to do

Precipitated withdrawal is a severe withdrawal reaction that can occur if buprenorphine (Suboxone) is started too soon.

If you experience sudden, dramatic worsening of withdrawal after starting buprenorphine (Suboxone), contact your provider in the Bicycle Health app for direction.

Time always resolves symptoms of precipitated withdrawal, but there are often medications that can ease discomfort while waiting.  Your Bicycle Health provider may direct you to use over-the-counter medications or prescribed medications for withdrawal symptoms to improve comfort while waiting to take your next dose of buprenorphine (Suboxone).

View Transcript

Precipitated withdrawal is a severe withdrawal reaction that can occur if Suboxone is started too soon. Generally, it is not medically dangerous but is extremely uncomfortable and can last from several hours to a day. If you experience sudden, dramatic worsening of your withdrawal after starting Suboxone, contact your provider in the Bicycle Health app for direction. They will assess your symptoms and give direction about wait times and further doses of Suboxone to alleviate your symptoms. Time will always resolve precipitated withdrawal, but to minimize symptoms while waiting you may use any “comfort” medications that have been provided to you for withdrawal symptoms. If you experience dizziness, sedation, or difficulty breathing, contact emergency services.

Day 1 - Dose 2

If it’s been 2 hours since your first dose of Suboxone, consider how you’re feeling right now.

Are you still feeling discomfort from opioid withdrawal?

Yes

  • This is normal.  
  • Now, place 2mg of buprenorphine under your tongue.
  • This is one-quarter (¼) of an 8mg film or tablet.
  • Wait until it is completely dissolved.  This takes 10 minutes.
  • Once completely dissolved, it’s ok to either swallow or spit any remaining saliva in your mouth.
  • After the medication dissolves, it’s normal to feel either a little better, a little worse, or no change at all.  30 to 60 minutes after this dose, you can expect to start feeling noticeably better.  
  • Be sure not to take your third dose until at least 1 hour has passed since your second dose.  After 1 hour, proceed to the next video segment.

No

  • That’s an uncommonly good response to the first dose.  Wonderful!  You have taken enough buprenorphine for today.  Do not take any more buprenorphine now.
  • Your total dose of buprenorphine for today was 2mg. Write that down because you’ll need to remember it tomorrow. Return to the Day 2 video segment tomorrow.

Day 1 - Dose 3

If it’s been 1 hour since your second dose of Suboxone, consider how you’re feeling right now. 

Are you still feeling discomfort from opioid withdrawal?

Yes

  • This is normal.  
  • Now, place 4mg of buprenorphine under your tongue.
  • This is one-half of an 8mg film or tablet.
  • Wait until it is completely dissolved.  This takes 10 minutes.
  • Once completely dissolved, it’s ok to either swallow or spit any remaining saliva in your mouth.
  • After the medication dissolves, it’s normal to feel either a little better, a little worse, or no change at all.  30 to 60 minutes after this dose, you can expect to start feeling noticeably better.  
  • Be sure not to take your third dose until at least 1 hour has passed since your second dose.  After 1 hour, proceed to the next video segment.

No

  • That’s an uncommonly good response to the second dose.  Wonderful!  You have taken enough buprenorphine for today.
  • Your total dose of buprenorphine for today was 4mg. Write that down because you’ll need to remember it tomorrow. Return to the Day 2 video segment tomorrow.

Day 1 - Dose 4

If it’s been 1 hour since your third dose of Suboxone, consider how you’re feeling right now. 

Are you still feeling discomfort from opioid withdrawal?

Yes

  • This is normal.  
  • Now, place 4mg of buprenorphine under your tongue.
  • This is one-half of an 8mg film or tablet.
  • Wait until it is completely dissolved.  This takes 10 minutes.
  • Once completely dissolved, it’s ok to either swallow or spit any remaining saliva in your mouth.
  • After the medication dissolves, it’s normal to feel either a little better, a little worse, or no change at all.  30 to 60 minutes after this dose, you can expect to start feeling noticeably better.  
  • You have now taken your full Day 1 dose of buprenorphine, 12mg.  Write this down because you’ll need to remember it tomorrow.   
  • If you’re still feeling withdrawal, that’s normal.  Most patients reach a full effective dose of Suboxone on treatment day 2.  Be sure not to advance to the next step until at least 8 hours from now. 
  • Until then, if you can’t sleep it’s often helpful to keep busy with some relaxing activity and avoid focusing on your discomfort.   Here’s  a long list of possible activities here to help with waiting while feeling withdrawal: https://withdrawal.theinnercompass.org/coping/distractions.  If needed, over-the-counter medications can help manage symptoms.

No

  • That’s an uncommonly good response to the second dose.  Wonderful!  You have taken enough buprenorphine for today.
  • Your total dose of buprenorphine for today was 8mg.  Write that down because you’ll need to remember it tomorrow.  Return to the Day 2 video segment tomorrow.

Day 2

Be sure that at least 8 hours have passed since your last dose of buprenorphine.

If it’s been 8 hours since your first dose of Suboxone, consider how you’re feeling right now. 

Are you still feeling discomfort from opioid withdrawal?

Yes

  • This is normal.  
  • Review how much buprenorphine you took yesterday.  It will be either 2, 4, 8, or 12mg.  Now add 4 to that number - this is your daily dose for today.  It will NEVER be higher than 16.
  • Now, place your daily dose for today (yesterday’s total + 4) under your tongue.
  • Wait until it is completely dissolved.  This takes 10 minutes.
  • Once completely dissolved, it’s ok to either swallow or spit any remaining saliva in your mouth.
  • Continue to take this same dose once daily each morning until you see your Bicycle Health provider again.

No

  • That’s a great response to the first day of treatment.
  • Review how much buprenorphine you took yesterday.  It will be either 2, 4, 8, or 12mg.  This is your daily dose for today.  It will NEVER be higher than 16.
  • Now, place your daily dose for today (yesterday’s total) under your tongue.  
  • Wait until it is completely dissolved.  This takes 10 minutes.
  • Once completely dissolved, it’s ok to either swallow or spit any remaining saliva in your mouth.
  • Continue to take this same dose once daily each morning until you see your Bicycle Health provider again.

Induction Completed

Congratulations! You’ve started treatment successfully. We’re here to work with you toward ongoing success.

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Congratulations! You’ve made it through one of the hardest parts of treatment! Now that you’ve completed your induction onto Suboxone, your provider will guide you on next steps during your follow-up visits. Together, you will work towards finding a daily, consistent therapeutic dose of Suboxone that relieves opioid cravings and helps your brain start healing from opioid use disorder.

In addition to visits with your medical provider, Bicycle Health offers many services that may be helpful to patients early in treatment. You can ask your provider about them or reach out on the Bicycle Health app. Congratulations again!

More resources for your plan

Accidental Overdose

If you accidentally take more buprenorphine (Suboxone) than directed, this is usually not medically dangerous. buprenorphine (Suboxone) has a ceiling effect which usually occurs between 24 and 16 mg. This means at the sealing dose; the medication is causing its maximum effect, and taking more will have no additional positive or negative effect. There are exceptions to this rule:

  • If you have taken more buprenorphine (Suboxone) than directed and you begin to have dizziness, sedation, or you have difficulties breathing, please reach out and call 911. 
  • If you have taken more than directed and you’re feeling fine, that’s okay. Then let’s you Bicycle Health provide know as soon as possible.  Continue your usuals directed dose until you hear back from them.
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If you accidentally take more buprenorphine than directed, this usually is not medically dangerous. Buprenorphine has a “ceiling effect” which usually occurs at somewhere between 16 and 24mg. This means, that at this ceiling dose, the medication is causing its maximum effect, and taking more will have no additional positive or negative effect. There are exceptions to every rule though: if you have taken more buprenorphine than directed and are feeling dizzy, sedated, or having difficulty breathing, call 911. If you’ve taken more than directed and are feeling fine, then let your Bicycle Health provider know as soon as possible. Continue your usual directed dose until you hear back from your provider.

Missed doses

It’s best to avoid missing doses of buprenorphine (Suboxone), but it may happen, and it’s helpful to understand the following if you do:

If you miss a single dose, typically you’ll feel very little or no withdrawal.

If you miss 2 doses in-a-row, typically you will start to feel minimal withdrawal, but it’s rarely severe.

If you’ve realized that you’ve missed a dose, and your next usual dosing time is MORE THAN 8 HOURS away, go ahead and take your missed dose late.  Then continue your usual daily medication routine.

If you’ve realized that you’ve missed a dose, and your next usual dosing time is LESS THAN 8 HOURS away, consider how you feel.

Are you feeling discomfort from opioid withdrawal?

  • Yes
    Go ahead and take your missed dose now, then contact your Bicycle Health provider to ask about what to do for your next regularly scheduled dose.
  • No
    Wait for your next regularly scheduled dose, and take it as you usually would. Do not take your missed dose late or take any ‘make-up’ or extra dose.
View Transcript

Buprenorphine is an effective first-line medication for the treatment of opioid use disorder. Suboxone is the brand name for a combination of buprenorphine and naloxone. This is the medication we offer to patients here at Bicycle Health. Buprenorphine is an opioid that binds to the opiate receptors in the brain but only partly activates them. This relieves withdrawal symptoms, decreases cravings, and protects against relapse long-term by blocking other opioids from binding to the receptor. It’s usually a once daily medication. And because buprenorphine doesn’t fully stimulate the opioid receptor, there is no feeling of a “high” while taking the medication. It restores stability to the opioid receptors

The second ingredient, Naloxone, is used in conjunction with buprenorphine to help deter abusing the medication. It has no effect and is not even absorbed when the medication is dissolved in the mouth as directed; it helps prevent misuse of the medication by causing withdrawal injected.

Slips

A ‘slip’ is when you use another opioid in an unintentional or otherwise potentially harmful way while in care for opioid use disorder.

Slips are common.  The most important thing to do if you experience a slip is to continue taking buprenorphine (Suboxone) as you usually would.  Continued use of buprenorphine (Suboxone) helps improve your ability to stop a slip without progressing into uncontrolled ongoing opioid use, often called a ‘relapse.’  

Buprenorphine (Suboxone) helps you control a slip by inhibiting the ‘high’ you may otherwise get from other opioid, by reducing cravings, and by protecting against overdose.

Slips are common, and your Bicycle Health provider understands that.  Be sure to talk to your Bicycle Health provider about it if you experience a slip so they can partner with you to improve the effectiveness of your care.

View Transcript

If you miss a dose of buprenorphine (Suboxone), know that this is fairly common. If you are used to taking buprenorphine every day, a single missed dose will usually not cause withdrawal symptoms or negative effects. For many patients, up to 2 missed doses in a row will result in only minimal symptoms. More than 2 missed doses will begin to result in substantial withdrawal. Of course, it’s best never to miss a dose, but if there’s one important takeaway from this video, it’s that if you do miss a dose, it’s ok.

If you do remember that you’ve missed a dose, and it’s going to be more than 8 hours until your next dose, go ahead and take the missed dose late. Then continue as you usually would for the next dose. If the next scheduled dose is less than 8 hours away, and you’re feeling no symptoms of withdrawal, just wait for your next regular dose and do not take a make-up dose or any extra medication.

If your next scheduled dose is less than 8 hour away and you ARE feeling withdrawal, go ahead and take the missed dose, then contact your Bicycle Health provider to ask about what to do for the next scheduled dose.

Frequently asked questions

How do you prepare for your first dose of Suboxone?

  1. Check the strength of the medication. You have likely received either 8-2 mg or 2-0.5 mg films or tablets. The first number is the amount of buprenorphine,the active component of the medication, and this is the number we use when talking about the dose.
  2. You may need to cut the tablet or film to get  the correct  dose ordered by your Bicycle Health provider. To cut tablets, a pill-cutter works best.  To cut  films, a sharp and completely dry pair of scissors is best.
  3. After cutting the tablet or film to the correct dose, be sure to put the remaining portion back into the bottle or foil package to save for your next dose.

How do you take Suboxone?

Buprenorphine (Suboxone) can only be absorbed through the underside of your tongue and through the inside surfaces of your cheeks.  It cannot be absorbed through the stomach or intestines, so the medication will have NO EFFECT if swallowed.  It must dissolve completely under the tongue (prefered) or between your lower gum and cheek (secondary choice if unable to dissolve under the tongue).

When ready to take the medication, remember the following:

  • Do NOT swallow it.
  • Make sure nothing is in your mouth – no gum, no liquids, no food. 
  • Do NOT eat or drink anything until the medication is completely dissolved, which may take up to 15 minutes.
  • After the medication has completely dissolved and can no longer be felt or seen in the mouth, you may either swallow or spit out the remaining saliva, whichever you prefer.